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KMID : 0387919930040020105
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Korean Journal of Cytopathology
1993 Volume.4 No. 2 p.105 ~ p.110
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Fine Needle Aspiration Cytology of Follicular neoplasm of the Thyroid @AU 조경자, 장.
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조경자
장자준
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Abstract
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The major limitation of fine needle aspiration of the thyroid is in the evaluation of follicular tumors. lt may be difficult or occasionally, impossible to distinguish on a cytologic basis. between hyperplastic nodular goiter, follicular
adenoma and well differentiated follicular carcinoma. We reviewed cytologic presentations of 15 histologically confirmed follicular neoplasms of the thyroid. Aspiration smears of 6 follicular adenomas were cell-rich with ball-like
or
syncytial aggregates of monotonous follicular cells, in contrast to honeycomb-like flat sheets of adenomatous goiter Mild nuclear pleomorphism and a small visible nucleolus were noted in 2 cases, respectively. Nine cases of follicular
carcinoma
showed very high cellularity, irregularly shaped cell clusters, and numerous isolated tumor cells. Nuclear pleomorphism and visible nucleoli were noted in 6 and 5 cases, respectively, Another characteristic finding. entrapped
endothelial cells within the cell clusters, was noted in 7 carcinomas and 1 adenoma. The background of the smears of all follicular neoplasms was hemorrhagic, with no or scanty colloid. We confirmed that the cytologic features of
follicular
adenoma and carcinoma were similar in general, with subtle differences in cell morphology, but the presence of isolated tumor cells and entrapped endothelial cells was suggestive of malignancy.
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KEYWORD
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